Manganese Sulfate

Manganese sulfate is a mineral supplement that contains manganese and sulfur. It is used to prevent and treat manganese deficiency, a condition in which the body doesn’t have enough manganese. Manganese sulfate is sometimes included with chondroitin sulfate and glucosamine hydrochloride in multi-ingredient products promoted for osteoarthritis.

Here are some benefits of manganese sulfate:

• Bone health: Manganese may play a positive role in bone health by working in concert with other vitamins and minerals to improve bone mineral density.
• Antioxidant: Manganese is a part of the antioxidant enzyme superoxide dismutase (SOD), which is arguably one of the most important antioxidants in your body.
• PMS symptoms: When combined with calcium, manganese may act as a natural remedy for decreasing PMS symptoms.
• Brain function: Manganese is essential for healthy brain function and often used to help treat specific nervous disorders.
• Wound healing: Manganese may help with wound healing by playing a role in collagen formation in skin cells, but more studies are needed.

According to the NIH Office of Dietary Supplements, there are no clinical trials that have evaluated the effects of manganese supplementation alone on bone health. However, in one small clinical trial, supplementation with calcium (1,000 mg) plus trace minerals (5 mg manganese, 15 mg zinc, and 2.5 mg copper) for 2 years improved spinal bone density compared with placebo in 59 postmenopausal women.

The recommended daily intake of manganese varies depending on age and sex. The Adequate Intake (AI) recommendation for adults is 1.8–2.3 mg per day. However, it’s important to note that taking more than 11 mg daily by mouth is possibly unsafe and can cause serious side effects.

Potential side effects of taking too much manganese include tremors, muscle spasms, hearing problems, mania, insomnia, depression, loss of appetite, headaches, irritability, weakness, and mood changes. People who should avoid manganese supplements or speak with a doctor first include those with existing liver disease or a history of alcoholism or anemia.

Sources:

1. https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/
2. https://ods.od.nih.gov/pdf/factsheets/Manganese-Consumer.pdf
3. https://www.webmd.com/vitamins/ai/ingredientmono-182/manganese
4. https://www.rxlist.com/manganese/supplements.htm
5. https://ods.od.nih.gov/factsheets/Manganese-Consumer/
6. https://www.healthline.com/nutrition/manganese-benefits