Cyclo-Chrysin
Cyclo-Chrysin is a supplement that contains chrysin, a flavonoid found in honey and propolis. Chrysin has been shown to inhibit the aromatase enzyme, which is responsible for estrogen biosynthesis.
Cyclo-Chrysin is marketed as a testosterone booster, although there is no good scientific evidence to support this claim. However, chrysin has been found to have other potential benefits. For example, it has anti-inflammatory and antioxidant properties, and it has been shown to have anxiolytic-like effects through GABAA receptors in a surgical menopause model in rats. Chrysin also regulates abnormal changes in enzyme activities induced by commonly used anticancer drugs.
A study showed that administration of chrysin in a dose of 40 mg/kg 24 hours prior to the treatment with mitomycin C caused regression of the genotoxic effect, which resulted partly from the high antioxidant activity of chrysin. The standard supplemental doses of chrysin (400-3,000mg) appear to be pretty much ineffective due to its poor bioavailability. There are no specific recommendations for the dosage of Cyclo-Chrysin.
Case studies:
- Chrysin administered to rats (25 and 50 mg/kg) seven days prior to treatment with a single dose of cyclophosphamide (200 mg/kg) considerably reduced the toxic effects of this drug by regulating the activity of metabolic ROS removal.
- A study proved that chrysin reversed the harmful side-effects of some nonsteroidal anti-inflammatory drugs, such as diclofenac.
- Chrysin (0.5, 1, 2, and 4 mg/kg) was evaluated in the elevated plus maze, light/dark test, and open field test in a surgical menopause model in rats. The results showed that chrysin exerts anxiolytic-like effects through GABAA receptors.
Sources:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063143/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232110/
- https://examine.com/supplements/chrysin/
- https://www.webmd.com/vitamins/ai/ingredientmono-1047/chrysin
- https://www.sciencedirect.com/science/article/pii/S1018364722002075
- https://www.sciencedirect.com/science/article/pii/S0753332218363546
