Tri-Sodium Citrate
Tri-sodium citrate is a compound that is widely used in the pharmaceutical and medical industries as an adjuvant or additive. It is commonly used for urine alkalinization and the prevention of nephrolithiasis (formation of kidney stones). In addition to its use as an anticoagulant, citrate also acts as a buffer and is used for hemodialysis.
Studies have shown that trisodium citrate has beneficial effects on cardiovascular and renal function in ischemia-induced acute kidney injury. It has also been found to significantly lower urinary pH and urinary uric acid excretion and decrease serum uric acid levels in allopurinol-treated individuals, effectively improving renal glomerular filtration.
The recommended dosage of trisodium citrate depends on the specific use case and should be determined by a healthcare professional. While trisodium citrate is generally safe to use, there are potential side effects such as an allergic reaction, dizziness, weakness, and restlessness. It is important to consult with a doctor or pharmacist before starting to use trisodium citrate, especially if taking other medications or having certain medical conditions.
Sources:
- https://www.rxlist.com/sodium_citrate_citric_acid/generic-drug.htm
- https://go.drugbank.com/drugs/DB09154
- https://persianutab.com/benefits-and-harms-of-trisodium-citrate-2/?lang=en
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231307/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387390/
- https://acutecaretesting.org/en/articles/use-of-tri-sodium-citrate-in-hemodialysis
