Synephrine HCL
Synephrine HCL is a compound found naturally in bitter orange. It is a stimulant that works by increasing the body’s metabolic rate, which in turn helps to burn calories and fat. Synephrine HCL is often used in dietary supplements to promote weight loss and improve athletic performance.
Benefits of Synephrine HCL
Synephrine HCL has been shown to have several benefits, including weight loss, increased energy, and improved athletic performance. A study found that the use of synephrine HCL, at doses of up to 3 mg/kg, offers some benefits over other substances such as caffeine due to the lower rate of side effects. Another clinical study found that the combination of synephrine with caffeine did not cause any serious adverse effects. Additionally, synephrine has been shown to have bronchodilator effects, making it useful in the treatment of bronchial asthma.
Case Studies on the Benefits of Synephrine HCL
A clinical study found that synephrine did not cause any adverse effects with respect to heart rate, blood pressure, blood chemistry, or blood cell count with differentials, indicating the safety of synephrine. Another study showed that synephrine supplementation resulted in weight loss without any adverse effects while also providing an antioxidant and tissue-protective effect.
Recommended Dosage and Potential Side Effects
The recommended dose of synephrine is 32 mg per day. However, there is no safe and effective dose of synephrine because no sufficiently powered study has been conducted to find one. Reported side effects of synephrine-containing supplements include hallucinations/psychosis, coronary spasms and thrombosis, and heart rhythm disturbances (ventricular fibrillation). A study of mice showed high rates of serious side effects, including gasping and reduced motor function, when high doses of synephrine were used. Therefore, it is important to consult a healthcare provider before taking synephrine HCL or any dietary supplement.
Sources:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830131/
- https://www.dovepress.com/effects-of-p-synephrine-in-combination-with-caffeine-a-review-peer-reviewed-fulltext-article-NDS
- https://www.webmd.com/vitamins/ai/ingredientmono-976/bitter-orange
- https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/synephrine
- https://supplements.selfdecode.com/blog/synephrine/
- https://www.rivm.nl/bibliotheek/rapporten/2017-0069.pdf
