Sulbutiamine
Sulbutiamine is a synthetic molecule that is a modified derivative of vitamin B1. It is used for the treatment of weakness, fatigue, and to enhance athletic performance, among other conditions. According to a review article, sulbutiamine has been found to have various effects on the brain that might improve memory and reduce feelings of weakness. However, there is no good scientific evidence to support these uses.
There are a limited number of studies conducted on sulbutiamine and methodological concerns need to be addressed. Nevertheless, some studies reported that sulbutiamine has some health applications and benefits. For instance, a study showed that sulbutiamine supplementation improved attention, memory, and mood in healthy people. Another study reported that sulbutiamine improved cognitive function in people with Alzheimer’s disease. A study also found that sulbutiamine reduced fatigue in patients with multiple sclerosis.
The recommended dosage of sulbutiamine depends on several factors such as the user’s age, health, and several other conditions. According to RxList, a dose of 600 mg daily has been used safely for up to 4 weeks. However, the optimal dosing regimen is not currently known.
According to a review article, sulbutiamine is generally well-tolerated, and adverse effects are rare and usually mild in nature. Some people taking sulbutiamine have reported nausea, headache, tiredness, and inability to sleep. A study reported that only 15 patients using sulbutiamine presented side effects such as headache, agitation, palpitations, diarrhea, cough, sinusitis, cystitis, bronchitis, osteoarthritic and low back pain, tremor, and drowsiness.
Sources:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381637/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832132/
- https://pubmed.ncbi.nlm.nih.gov/30786889/
- https://www.nlm.nih.gov/pubs/techbull/ma08/ma08_simplified_web_links.html
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896816/
- https://neuropedia.com/all-about-sulbutiamine-science/
