Isatis Leaf Extract

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Isatis leaf extract is derived from the leaves of the Isatis plant, which grows in China. It has been used in traditional Chinese medicine (TCM) for centuries to reduce fever and swelling, and to treat a variety of conditions such as aging skin, scaly itchy skin (psoriasis), diarrhea, and prostate cancer. Isatis leaf extract contains chemicals that might keep cancer cells from multiplying. However, there is no good scientific evidence to support most of these uses.

Benefits of Isatis Leaf Extract:
  • Reduces fever and swelling
  • Contains chemicals that might keep cancer cells from multiplying
  • Used for aging skin, scaly itchy skin (psoriasis), diarrhea, and prostate cancer
Case Studies:
  • A small randomized study demonstrated the utility of an isatis root extract solution to reduce the severity of radiation mucositis, anorexia, and swallowing difficulty in head and neck cancer patients.
  • A hydroalcoholic leaf extract of Isatis tinctoria L. was able to reverse the behavioral response to restraint by a mechanism partially dependent on the modulation of oxidative stress, neuroinflammation, and nitric oxide reduction.

For scaly, itchy skin (psoriasis): A specific product containing a chemical in isatis called indigo naturalis as an oil extract (Lindioil), applied in doses of 0.05-0.1 mL to nail folds and the skin beneath the edge of the nail twice daily for 24 weeks, has been used. When applied to the skin, Isatis is possibly safe when used appropriately, short-term. A specific product containing an isatis leaf extract called indigo naturalis in olive oil (Lindioil) has been used safely for 24 weeks. There isn’t enough reliable information to know if it’s safe to use during pregnancy or breastfeeding.

Sources:
  1. https://www.webmd.com/vitamins/ai/ingredientmono-911/isatis
  2. https://www.rxlist.com/isatis/supplements.htm
  3. https://www.mskcc.org/cancer-care/integrative-medicine/herbs/isatis-root
  4. https://www.mskcc.org/cancer-care/integrative-medicine/herbs/isatis-leaf
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249990/
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252841/

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