Fisetin 98% HPLC

Fisetin is a flavonoid, a type of phytonutrient found in various fruits and vegetables such as strawberries, apples, and persimmons. It has been the subject of interest due to its potential health benefits. When used as a health supplement, fisetin is often standardized to 98% purity using High-Performance Liquid Chromatography (HPLC), a method to identify and purify the compounds in a substance.

Benefits of Fisetin 98% HPLC:

1. Anti-aging: Fisetin has demonstrated a unique ability to enhance the body’s natural defenses against aging by reducing the impact of aging at the cellular level. Studies have indicated it promotes the cleaning of aged and damaged cells, a process known as senescence.
2. Antioxidant: As a flavonoid, fisetin possesses strong antioxidant properties, which help protect the body’s cells from damage by free radicals.
3. Neuroprotection: Fisetin has demonstrated neuroprotective properties in studies, suggesting it may help to maintain brain health and cognitive function.
4. Anti-inflammatory: It has potential anti-inflammatory effects which can benefit overall health.
5. Anti-cancer: Some studies have indicated that fisetin may have potential anti-cancer properties, although further research is required to conclusively establish this.

There is no set dosage for fisetin yet, but supplements generally fall in the 100-mg range, which is significantly higher than regular dietary sources. In the ongoing clinical trial looking at the effects of fisetin in older adults, fisetin is used at a higher dose of 20mg per kg of body weight for two consecutive days. This would be around 1,400mg per day for an average-sized person of 155 pounds—identical to the dose found in Neurohacker’s Qualia Senolytic.

As fisetin has not been studied for very long as a supplement, researchers aren’t entirely sure about its long-term effects. However, animal studies have not found any evidence of fisetin toxicity—even at very high doses. One case study found that fisetin is linked to better brain function by reducing neuroinflammation, fighting oxidative stress in the brain, and clearing senescent cells. Another study found that fisetin treatment resulted in dose-dependent inhibition of cancer cell growth and proliferation with concomitant induction of apoptosis.

Sources:

• https://longevity.technology/lifestyle/fisetin-everything-you-need-to-know/amp/
• https://www.sciencedirect.com/topics/chemistry/fisetin
• https://thenutritioninsider.com/wellness/fisetin-benefits/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291199/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689181/