Cortex Fraxetin 99.8%
Fraxetin is a natural coumarin derivative found in the Cortex Fraxini plant. It is an O-methylated coumarin with antioxidant, anti-inflammatory, and neuroprotective properties. Fraxetin has shown potential therapeutic benefits in various diseases and conditions, including cancer, osteoporosis, and inflammation
Benefits of Fraxetin
- Anticancer properties: Fraxetin has been demonstrated to inhibit the proliferation of certain cancer cells, such as breast cancer, melanoma, and hepatocellular carcinoma.
- Neuroprotection: Fraxetin has been shown to protect against rotenone-induced cytotoxicity in SH-SY5Y cells, potentially by reducing free radical formation. It has also been found to attenuate disrupted behavioral and central neurochemical activity in a model of chronic unpredictable stress.
- Anti-inflammatory and antioxidative effects: Fraxetin has been reported to inhibit osteoclastogenesis and protect against periprosthetic osteolysis by suppressing p38 signaling. It also alleviates lipid peroxidation, enhances hepatic antioxidant capabilities, and reduces inflammatory mediators.
- Anti-enteritis effect: Fraxetin incorporated into long circulating liposomes has been shown to improve oral bioavailability and enhance the anti-enteritis effect.
Case Studies and URLs
- Fraxetin protects rat brains from cerebral stroke via promoting angiogenesis and activating the PI3K/Akt pathway: https://www.tandfonline.com/doi/abs/10.1080/08923973.2022.2052893
- Fraxetin Interacts Additively with Cisplatin and Mitoxantrone, Antagonistically with Docetaxel in Various Human Melanoma Cell Lines6: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820609/
- Fraxetin attenuates disrupted behavioral and central neurochemical activity in a model of chronic unpredictable stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078985/
There is no standardized recommended dosage of Fraxetin for human consumption, as its therapeutic potential and safety are still being investigated. Dosages used in animal studies and in vitro experiments vary depending on the specific application. For example, one study used oral administration of 40 mg/kg fraxetin in a rat model of renal interstitial fibrosis.
Sources:
- https://www.tandfonline.com/doi/abs/10.1080/08923973.2022.2052893
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820609/
- https://www.sciencedirect.com/topics/chemistry/fraxetin
- https://www.spandidos-publications.com/10.3892/ol.2017.7143
- https://www.selleckchem.com/products/fraxetin.html
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310265/
- https://pubchem.ncbi.nlm.nih.gov/compound/Fraxetin
