Chrysin 98%

Chrysin 98% is a bioflavonoid compound found in high levels in propolis and honey. It is most well-known for being a testosterone-boosting plant compound, although this seems to be a misleading claim. While it has mechanisms of action that would lead to the conclusion that it could boost testosterone, these both occur at significantly higher oral doses than are seen with oral supplementation. Chrysin appears to be poorly absorbed, and even then it is readily metabolized resulting in insufficient levels in the blood and testes to exert these beneficial effects.

Here are some benefits of Chrysin 98%:

• Inhibitory effect on estrogen biosynthesis: Chrysin has been shown to suppress the enzyme aromatase (CYP19), which is involved in estrogen biosynthesis.
• Protective effects against neurological conditions: Chrysin has protective effects against neurological conditions by modulating oxidative stress, inflammation, and apoptosis in animal models.

There are several case studies regarding the benefits of Chrysin 98%. For example, a systematic review found that chrysin reduced fertility in roosters and increased the concentration of aromatase inhibitors. However, the standard supplemental doses of chrysin (400-3,000mg) appear to be pretty much ineffective due to its poor bioavailability.

The recommended dosage of Chrysin 98% is not clear due to its poor bioavailability but the doses used in reviewing studies were between the range of 0.5 and 5 μM. There are no known potential side effects of Chrysin 98%. However, there isn’t enough reliable information to know if chrysin is safe to use when pregnant or breastfeeding.

Sources:

• Inhibitory effect of chrysin on estrogen biosynthesis by suppression of enzyme aromatase (CYP19): A systematic review – NCBI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063143/
• Chrysin — Health benefits, dosage, safety, side-effects, and more | Supplements – Examine: https://examine.com/supplements/chrysin/
• CHRYSIN: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews – WebMD: https://www.webmd.com/vitamins/ai/ingredientmono-1047/chrysin
• Chrysin: Health Benefits, Side Effects, Uses, Dose & Precautions – RxList: https://www.rxlist.com/chrysin/supplements.htm
• Developing nutritional component chrysin as a therapeutic agent: Bioavailability and pharmacokinetics consideration, and ADME mechanisms – ScienceDirect: https://www.sciencedirect.com/science/article/pii/S0753332221008635
• An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches – ScienceDirect: https://www.sciencedirect.com/science/article/pii/S0753332221006880