Saffron
Saffron is a spice derived from the flower of Crocus sativus and is used both as a culinary ingredient and for medicinal purposes. Saffron is used to treat a variety of conditions including depression, anxiety, Alzheimer’s disease, menstrual cramps, premenstrual syndrome (PMS), and sleep problems.
Saffron is possibly safe when taken as a medicine in doses up to 100 mg daily for up to 26 weeks. However, taking large amounts of saffron by mouth is possibly unsafe. High doses of 5 grams or more can cause poisoning and doses of 12-20 grams can cause death. Some common side effects of saffron include drowsiness, stomach problems, dry mouth, anxiety, dizziness, nausea, change in appetite, and headache. Allergic reactions can also occur in some people.
There are some potential benefits of taking saffron as a supplement or as a spice. According to, saffron is possibly effective for Alzheimer’s disease and depression. Additionally, a study published in found that taking a saffron extract supplement improved mood and well-being in healthy adults. Other studies have examined the effects of saffron on neuropsychiatric diseases, and have suggested that saffron constitutes an effective treatment for depression, anxiety, and schizophrenia.
When taking saffron as a supplement, it is recommended to take it twice a day in a supplement form or at meals as a spice. Doses above 1,200 mg may cause nausea and vomiting. It is important to follow recommended dosages and to speak to a healthcare provider before starting any supplement regimen.
