Rutaecarpine
Rutaecarpine is an alkaloid found in the unripe fruit of Evodia rutaecarpa, which has been traditionally used in Asia to treat hypertension, dysentery, abdominal pain, headache, postpartum hemorrhage, and amenorrhea.
Here are some benefits of Rutaecarpine:
- Cardiovascular protective agent: Rutaecarpine has been shown to have cardiovascular biological effects such as inotropic and chronotropic, vasorelaxant, anti-platelet, and beneficial effects on some cardiovascular diseases.
- Liver injury protection: Rutaecarpine can protect against acetaminophen-induced acute liver injury in mice by activating antioxidant enzymes.
- Anticancer drug sensitivity: Rutaecarpine can increase anticancer drug sensitivity in drug-resistant cells through MARCH8-dependent ABCB1 degradation.
- Caffeine processing: Rutaecarpine can help process caffeine, which is why it is found in some pre-workout supplements.
The recommended dosage of Rutaecarpine is not clear as there is no official recommendation, but studies have used different doses depending on the intended use. For example, a study used 20 mg/kg of rutaecarpine for liver injury protection.
There are not many studies on the potential side effects of Rutaecarpine. However, one source mentioned that it may be toxic to the liver. Another source reported that rutaecarpine can induce hypothermia in mice at high doses. Further research is needed to determine the safety and side effects of rutaecarpine.
