MCC (microcrystalline cellulose)
Microcrystalline cellulose (MCC) is a white, odorless, and tasteless powder made from plant matter such as wood pulp and tough plant stalks. It is non-digestible and is commonly used as a food additive and pharmaceutical excipient due to its inert and flavorless characteristics. MCC is also used in the production of tablets, where it can influence the texture of the tablet without affecting its flavor.
Benefits of Microcrystalline Cellulose (MCC)
MCC has several benefits, including its use as a dietary fiber supplement. It can help reduce blood sugar levels and lessen the absorption of some medications. MCC can also be used to enhance gastrointestinal retention and drug delivery. A study showed that MCC can promote superior direct compressed Boesenbergia rotunda extract tablet properties compared to spray-dried rice starch and spray-dried lactose.
Case Studies Regarding the Benefits of MCC
A study investigated the effect of MCC crystallinity on the hydrophilic properties of tablets and the hydrolysis of active pharmaceutical ingredient, acetylsalicylic acid (ASA), inside tablets by using tablets containing 20% MCC as an excipient. The study found that a decrease in the crystallinity of MCC made it possible to pack the tablet tightly, which resulted in a delay in dissolution.
Another study characterized high amylose starch-microcrystalline cellulose based floatable gel for enhanced gastrointestinal retention and drug delivery. The study found that for the increase in the microcrystalline cellulose concentration in the gel, the loading efficiency and release of glycyrrhizic acid was decreased.
Recommended Dosage and Potential Side Effects
The recommended dosage for MCC varies depending on the intended use. As a dietary fiber supplement, it is recommended to start with small doses to minimize intestinal gas. MCC in certain fiber supplements may cause mild side effects such as gas, bloating, and increased stool production.
Sources:
- https://community.bulksupplements.com/microcrystalline-cellulose/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508302/
- https://www.sciencedirect.com/science/article/pii/S2666893922000032
- https://iopscience.iop.org/article/10.1088/1757-899X/368/1/012042/pdf
- https://www.tandfonline.com/doi/full/10.1080/25765299.2022.2153527
