Hypromellose Cellulose
Hypromellose Cellulose, also known as hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, and viscoelastic polymer that forms a colloid solution when dissolved in water. It is commonly used as an excipient in pharmaceuticals, particularly in films used for tablet coatings and hard capsule shells.
The benefits of Hypromellose Cellulose include its ability to improve the strength, oxygen permeability, water vapor transmission, clarity, and haze of films used for capsules and tablet coatings. A study found that changes to HPMC dispersion and hydration conditions can impact its performance properties. Another study found that HPMC is safe for all animal species when used under the proposed conditions of use.
The recommended dosage of Hypromellose Cellulose varies depending on the intended use and formulation. For example, as a binder, HPMC is used at the concentration of 2%–5% w/w. As an artificial tear to prevent conjunctival and corneal damage due to impaired lacrimal secretions, it is applied topically to the eye. There are no known serious side effects of Hypromellose Cellulose. However, some people may experience mild irritation or redness when using it as an eye drop. Overall, Hypromellose Cellulose is a versatile and safe excipient with many benefits for pharmaceutical formulations.
Case studies:
- Effect of Formulation Conditions on Hypromellose Performance Properties in Films Used for Capsules and Tablet Coatings: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513457/
- Safety and efficacy of hydroxypropyl methyl cellulose for all animal species: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395937/
