Glycine Propionyl L-Carnitine HCL

Glycine Prop​​ionyl L-Carnitine H​​CL (GPLC) is a​​ compound consisting​​ of joined carn​​itine and prop​​ionic acid molecules​​, with an additional​​ glycine component. L-carnitine plays​​ a vital role​​ in fatty acid​​ transport into​​ the cells, where​​ they are processed​​ for energy, while​​ propionic acid​​ acts as a precursor​​ to glucose production​. GPLC has​​ been associated​​ with various​​ health benefits​​, including:​

1. Energy production: GPLC helps produce energy needed by the body for its everyday demands, which can help avoid energy crashes that are common from so-called “sugar highs”
2. Reduced lipid peroxidation: GPLC reduces lipid peroxidation, which can seriously damage cell membranes.
3. Elevated nitric oxide levels: GPLC has been shown to increase nitric oxide levels, which is vital for blood flow and has been linked with exercise performance, especially in people with peripheral arterial disease.

Case Studies

1. A study published in the Journal of the International Society of Sports Nutrition found that short-term administration of GPLC significantly elevated levels of nitric oxide metabolites at rest in both sedentary and trained persons.
2. Another study published in the same journal investigated the long-term effects of GPLC supplementation on repeated anaerobic sprint performance and found that GPLC appears to be a useful dietary supplement to enhance anaerobic work capacity and potentially sport performance.

Recommended Dosage

​The standard​​ dose for L-carnitine, which​​ includes GPL​​C, is between​​ 500-2,000 mg​​ per day. However​​, some sources​​ recommend a dosage​​ of 1.5 to 4 grams​​ of GPLC powder​​ taken 30 to​​ 45 minutes before​​ exercise.

Potential Side Effects

​While L-carnitine supplements​​, including GPL​​C, are generally​​ considered safe​​, doses of approximately​​ 3 g/day can cause​​ nausea, vomiting​​, abdominal cr​​amps, diarrhea​​, and a fishy body​​ odor. It​​ can also cause​​ muscle weakness​​ in people with​​ uremia and seizures​​ in those with​​ a predisposition.

Sources

1. https://ods.od.nih.gov/factsheets/Carnitine-HealthProfessional/
2. https://www.science.gov/topicpages/g/glycine+propionyl-l-carnitine+produces
3. https://www.tsmp.com.au/blog/propionyl-l-carnitine.html
4. https://examine.com/supplements/carnitine/
5. https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-35
6. https://journals.humankinetics.com/view/journals/ijsnem/18/1/article-p19.xml
7. https://www.webmd.com/vitamins/ai/ingredientmono-803/propionyl-l-carnitine
8. https://www.healthline.com/nutrition/l-carnitine